Research

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Cell-therapy for Parkinson’s disease: a systematic review and meta-analysis

By Dr. Cremata, DC | June 14, 2024 |

Abstract Background: Cell-based strategies focusing on replacement or protection of dopaminergic neurons have been considered as a potential approach to treat Parkinson’s disease (PD) for decades. However, despite promising preclinical results, clinical trials on cell-therapy for PD reported mixed outcomes and a thorough synthesis of these findings is lacking. We performed a systematic review and…

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The potential use of mesenchymal stem cells and their exosomes in Parkinson’s disease treatment

By Dr. Cremata, DC | June 14, 2024 |

Abstract Parkinson’s disease (PD) is the second most predominant neurodegenerative disease worldwide. It is recognized clinically by severe complications in motor function caused by progressive degeneration of dopaminergic neurons (DAn) and dopamine depletion. As the current standard of treatment is focused on alleviating symptoms through Levodopa, developing neuroprotective techniques is critical for adopting a more…

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Clinical efficacy and safety of stem cell therapy for knee osteoarthritis

By Dr. Cremata, DC | June 14, 2024 |

Abstract Background: We performed a meta-analysis of the efficacy and safety of stem cell therapy as a clinical treatment of knee osteoarthritis. This meta-analysis is expected to provide evidence of the efficacy of stem cell therapy, which is currently controversial, as a conservative treatment for knee osteoarthritis.Methods: An online search for relevant articles was conducted…

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Umbilical cord-derived Wharton’s jelly for regenerative medicine applications

By Dr. Cremata, DC | June 12, 2024 |

Download the PDF for the full article, the abstract is blow Abstract Background: The last decade has seen an explosion in the interest in using biologics for regenerative medicine applications, including umbilical cord-derived Wharton’s Jelly. There is insufficient literature assessing the amount of growth factors, cytokines, hyaluronic acid, and extracellular vesicles including exosomes in these…

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Exosomes from acellular Wharton’s jelly of the human umbilical cord promote skin wound healing

By Dr. Cremata, DC | June 12, 2024 |

Download the PDF for the full document. Below is the Abstract. Abstract Background: Compromised wound healing has become a global public health challenge which presents a significant psychological, financial, and emotional burden on patients and physicians. We recently reported that acellular gelatinous Wharton’s jelly of the human umbilical cord enhances skin wound healing in vitro…

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