Research
Download the full article hronic neuropathic pain is estimated to be on the rise, particularly with the expected increase in patients with diabetes within the US. Diabetic and nondiabetic patients were surveyed for sick days fromwork due to neuropathic pain; approximately two-thirds of these patients were found to consistently be taking days from work, and…
Read More ABSTRACT Mesenchymal stem cells (MSCs) are very attractive candidates in cell-based strategies that targetinflammatory diseases. Preclinical animal studies and many clinical trials have demonstrated thathuman MSCs can be safely administered and that they modify the inflammatory process in thetargeted injured tissue. Our laboratory developed a novel method that optimizes the anti-inflammatory effects of MSCs. We…
Read More Objective: Mesenchymal stem cells (MSCs) have been shown in animal models to attenuatechronic neuropathic pain. This preliminary study investigated if: i) injections of autologousMSCs can reduce human neuropathic pain and ii) evaluate the safety of the procedure. Methods: Ten subjects with symptoms of neuropathic trigeminal pain underwent liposuction.The lipoaspirate was digested with collagenase and washed…
Read More A nonphysiological repair of the lesioned nerve leading to the formation of neurinomas, altered nerveconduction, and spontaneous firing is considered the main cause of the events underlying neuropathicpain. It was investigated whether neural stem cell (NSCs) administration could lead to a physiologicalnerve repair, thus to a reduction of neuropathic pain symptoms such as hyperalgesia and…
Read More Abstract Background: Cell-based strategies focusing on replacement or protection of dopaminergic neurons have been considered as a potential approach to treat Parkinson’s disease (PD) for decades. However, despite promising preclinical results, clinical trials on cell-therapy for PD reported mixed outcomes and a thorough synthesis of these findings is lacking. We performed a systematic review and…
Read More Abstract Parkinson’s disease (PD) is the second most predominant neurodegenerative disease worldwide. It is recognized clinically by severe complications in motor function caused by progressive degeneration of dopaminergic neurons (DAn) and dopamine depletion. As the current standard of treatment is focused on alleviating symptoms through Levodopa, developing neuroprotective techniques is critical for adopting a more…
Read More Abstract Background: We performed a meta-analysis of the efficacy and safety of stem cell therapy as a clinical treatment of knee osteoarthritis. This meta-analysis is expected to provide evidence of the efficacy of stem cell therapy, which is currently controversial, as a conservative treatment for knee osteoarthritis.Methods: An online search for relevant articles was conducted…
Read More Download the PDF for the full article, the abstract is blow Abstract Background: The last decade has seen an explosion in the interest in using biologics for regenerative medicine applications, including umbilical cord-derived Wharton’s Jelly. There is insufficient literature assessing the amount of growth factors, cytokines, hyaluronic acid, and extracellular vesicles including exosomes in these…
Read More Download the PDF for the full document. Below is the Abstract. Abstract Background: Compromised wound healing has become a global public health challenge which presents a significant psychological, financial, and emotional burden on patients and physicians. We recently reported that acellular gelatinous Wharton’s jelly of the human umbilical cord enhances skin wound healing in vitro…
Read More