Dr. Edward Cremata, DC, FNP-C
Director
NEW HEART ATTACK STUDY (MI) ADDED.
Cell therapy is a potentially useful approach to treating heart failure (HF) secondary to chronic ischemic cardiomyopathy (ischemic HF). Despite controversy, the preclinical data in the field of cell therapy are clear: Although transplanted cells do not regenerate cardiomyocytes, preclinical studies have consistently shown that they improve cardiac performance. Bone marrow–derived mesenchymal stromal cells (MSCs)…
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Advances in Stem Cell Therapies for Rotator Cuff Injuries
Rotator cuff injury is a common upper extremity musculoskeletal disease that may lead to persistent pain and functional impairment. Despite the clinical outcomes of the surgical procedures being satisfactory, the repair of the rotator cuff remains problematic, such as through failure of healing, adhesion formation, and fatty infiltration. Stem cells have high proliferation, strong paracrine…
Read More Stem cell therapies in tendon-bone healing
Abstract Tendon-bone insertion injuries such as rotator cuff and anterior cruciate ligament injuries are currently highly common and severe. The key method of treating this kind of injury is the reconstruction operation. The success of this reconstructive process depends on the ability of the graft to incorporate into the bone. Recently, there has been substantial…
Read More Intratendinous Injection of AutologousAdipose Tissue-Derived MesenchymalStem Cells for the Treatment of RotatorCuff Disease: A First-In-Human Trial
ABSTRACT Despite relatively good results of current symptomatictreatments for rotator cuff disease, there has been an unmetneed for fundamental treatments to halt or reverse the progressof disease. The purpose of this study was to assess the safety andefficacy of intratendinous injection of autologous adiposetissue-derived mesenchymal stem cells (AD MSCs) in patientswith rotator cuff disease. The…
Read More Mesenchymal Stem Cells From a Hypoxic Culture Can Improve Rotator Cuff Tear Repair
Abstract A rotator cuff tear is an age-related common cause of pain and disability. Studies including our previously published ones have demonstrated that mesenchymal stem cells cultured under hypoxic conditions [hypoxic multipotent stromal cells (MSCs)] facilitate the retention of transplanted cells and promote wound healing. However, there are very few, if any, reports targeting the…
Read More Phase I trial of hES cell-derived dopaminergic neurons for Parkinson’s disease
Parkinson’s disease is a progressive neurodegenerative condition with a considerable health and economic burden1. It is characterized by the loss of midbrain dopaminergic neurons and a diminished response to symptomatic medical or surgical therapy as the disease progresses. Cell therapy aims to replenish lost dopaminergic neurons and their striatal projections by intrastriatal grafting. Here, we…
Read More Repeated Intravenous Administration of Mesenchymal Stromal Cells Produces Cumulative Beneficial Effects in Chronic Ischemic Cardiomyopathy
Cell therapy is a potentially useful approach to treating heart failure (HF) secondary to chronic ischemic cardiomyopathy (ischemic HF). Despite controversy, the preclinical data in the field of cell therapy are clear: Although transplanted cells do not regenerate cardiomyocytes, preclinical studies have consistently shown that they improve cardiac performance. Bone marrow–derived mesenchymal stromal cells (MSCs)…
Read More Parkinson’s Patients Say Their Symptoms Eased After Receiving Millions of New Brain Cells
Grabbing a coffee cup seems easy. But you need to be able to move your hand, stretch it out, and keep it steady. These movements are difficult for people with Parkinson’s disease. The disorder eats away at brain cells—called dopamine neurons—that control movement and emotion. Symptoms begin with tremors. Then muscles lock up. Eventually, the…
Read More Potential role of stem cells for neuropathic pain disorders
Download the full article Chronic neuropathic pain is estimated to be on the rise, particularly with the expected increase in patients with diabetes within the US. Diabetic and nondiabetic patients were surveyed for sick days fromwork due to neuropathic pain; approximately two-thirds of these patients were found to consistently be taking days from work, and…
Read More Paralyzed man who can walk again shows potential benefit of stem cell therapy
A man who was paralyzed from the neck down after a surfing accident seven years ago is now able to stand and walk ok his own, thanks in part to a potentially groundbreaking stem cell treatment
Read More Anti-Inflammatory Mesenchymal Stem Cells (MSC2)Attenuate Symptoms of Painful Diabetic PeripheralNeuropathy
ABSTRACT Mesenchymal stem cells (MSCs) are very attractive candidates in cell-based strategies that targetinflammatory diseases. Preclinical animal studies and many clinical trials have demonstrated thathuman MSCs can be safely administered and that they modify the inflammatory process in thetargeted injured tissue. Our laboratory developed a novel method that optimizes the anti-inflammatory effects of MSCs. We…
Read More A preliminary report on stem cell therapy for neuropathic pain in humans
Objective: Mesenchymal stem cells (MSCs) have been shown in animal models to attenuatechronic neuropathic pain. This preliminary study investigated if: i) injections of autologousMSCs can reduce human neuropathic pain and ii) evaluate the safety of the procedure. Methods: Ten subjects with symptoms of neuropathic trigeminal pain underwent liposuction.The lipoaspirate was digested with collagenase and washed…
Read More Intravenous neural stem cells abolish nociceptive hypersensitivity and trigger nerve regeneration in experimental neuropathy
A nonphysiological repair of the lesioned nerve leading to the formation of neurinomas, altered nerveconduction, and spontaneous firing is considered the main cause of the events underlying neuropathicpain. It was investigated whether neural stem cell (NSCs) administration could lead to a physiologicalnerve repair, thus to a reduction of neuropathic pain symptoms such as hyperalgesia and…
Read More Cell-therapy for Parkinson’s disease: a systematic review and meta-analysis
Abstract Background: Cell-based strategies focusing on replacement or protection of dopaminergic neurons have been considered as a potential approach to treat Parkinson’s disease (PD) for decades. However, despite promising preclinical results, clinical trials on cell-therapy for PD reported mixed outcomes and a thorough synthesis of these findings is lacking. We performed a systematic review and…
Read More The potential use of mesenchymal stem cells and their exosomes in Parkinson’s disease treatment
Abstract Parkinson’s disease (PD) is the second most predominant neurodegenerative disease worldwide. It is recognized clinically by severe complications in motor function caused by progressive degeneration of dopaminergic neurons (DAn) and dopamine depletion. As the current standard of treatment is focused on alleviating symptoms through Levodopa, developing neuroprotective techniques is critical for adopting a more…
Read More Clinical efficacy and safety of stem cell therapy for knee osteoarthritis
Abstract Background: We performed a meta-analysis of the efficacy and safety of stem cell therapy as a clinical treatment of knee osteoarthritis. This meta-analysis is expected to provide evidence of the efficacy of stem cell therapy, which is currently controversial, as a conservative treatment for knee osteoarthritis.Methods: An online search for relevant articles was conducted…
Read More STEM CELL THERAPY
There are numerous published studies in the field of stem cell therapy over the past 20 years.
CONCIERGE-TYPE INDIVIDUALIZED AND PERSONALIZED FAMILY PRACTICE SERVICES. ALL PROCEDURES PERFORMED BY DR. CREMATA PERSONALLY.
REGENERATIVE HEALTH CARE WITH STEM CELL EMPHASIS. THESE CAN BE USED FOR MUSCULOSKELETAL CONDITIONS AS WELL AS CENTRAL NEUROLOGICAL CONDITIONS INCLUDING PARKINSONS DISEASE. WHILE STILL CONSIDERED EXPERIMENTAL, HIGH SUCCESS RATES ARE REPORTED BY MANY PATIENTS WITH STEM CELL TREATMENT.
HEALTH OPTIMIZATION INCLUDING HORMONE REPLACEMENT THERAPY